- PILL-FREE METHYLATION SUPPORT — A DAILY B-VITAMIN CREAM: For anyone who can’t or won’t swallow capsules. One pump a day delivers active, methylated B vitamins — methylfolate, methyl-B12, and P5P B6 — in a smooth cream, no pills required.
- ACTIVE, METHYLATED B VITAMINS — PLUS D3 & K1: Methylfolate (active B9), methyl- and hydroxo-B12, and P5P (active B6), with vitamin D3 and K1 — the pre-converted forms your body uses directly, in one daily topical.
- MADE FOR KIDS & PILL-AVERSE ADULTS: A simple option when capsules are a struggle — pill fatigue, a sensitive gag reflex, or kids who refuse oral vitamins. Apply one pump to thin skin daily: no water, no swallowing.
- EASY ONCE-DAILY APPLICATION: Apply one pump per day to clean, thin-skinned areas such as the inner wrist or forearm. 2 oz / ~120 pumps — about a four-month supply. Physician-formulated.
- PHYSICIAN-FORMULATED, PROFESSIONAL-GRADE: Developed by physicians and made in a GMP-certified facility. Non-GMO and free from unnecessary fillers — a clean, active-B-vitamin cream for daily use.

Lhray121 –
Highly recommend! Our story:
This was recommended to me for my kids who are extremely resistant to oral vitamins. I knew my oldest was at least D deficient and I was getting desperate as that deficiency was causing severe nightly growing pain and likely other issues as well. She has always been very petite in height and weight. At the start of using this, her growing pains got worse but after reading that it could be a bone remineralization process I decided to keep using it along with a magnesium lotion. We have been using this for 5 months and growing pains are almost nonexistent. In the first 6 weeks she grew almost a full inch. She has also gained 5lbs in the 5 months. Her annual checkup is in a few weeks and I’m excited to see how it reflects on her growth chart! (Will update with pictures!). I was skeptical about transdermal vitamins but the proof is too clear for our situation! Yes it’s orange, but it doesn’t bother me in the slightest. We rub it on the kids backs (morning back rub!) 3 times a week.
Caroline M. –
Been using a long time
Vitamin D and B are super important for any human but especially for me! This cream has helped me with overall wellness for quite some time, now.
ck –
Quality product/low quality shipping
The product itself seems to work well! I know it’s hard to judge these days which shipping to use, but I’ve come to expect items ordered on Amazon to be true to the shipping date. This was extremely late in comparison. This was an item I desperately needed to help restore my B12 levels and it was very frustrating to wait.
JJ –
Methylation Pro Topical Cream
This is a very good product for neuropathy of the hands. My elderly mother uses it and recomends.
BP –
easy to use
love tis product can’t take the pills
Did not realize that it was a sample size. –
Topical Vitamin Formula That Works
I had doubts about a topical vitamin solution, but I can feel the difference in my energy level.
Lori Silverman –
Use if MTHFR C homozygous
I have used this product for years. My daughter and I are homozygous for MTHFR C copy gene. She went to an MTHFR clinic and they specifically recommended this product. She started using it and so did I. My son hasn’t been tested but he’s using it too. A few weeks ago I missed a few days of use due to travel and I felt the difference. It definitely stabilizes my emotional state. I won’t be without it
H. FlanaganH. Flanagan –
New formula?New formula?
We’ve use the Neuro immune stabilizer on my son and it really worked! We ordered this methylation pro as it seems to be the replacement for the older product with similar ingredients and container. As others have stated, this seems to have pump issues and potentially be old product? It says it was manufactured in August 2022 and is brown and unpleasant smelling. I’m not familiar with cat diarrhea that the other reviewer mentioned but that would seem to be a possible accurate description. I’ve attached a photo of 6 pumps and you can see only 4 of those resulted in product being dispensed and in vastly different amounts.